Willebrand factor in von Willebrand's disease.

Willebrand factor in von Willebrand's disease.

Genetic Variation in the von Willebrand Factor Gene in Swedish von Willebrand Disease Patients

von Willebrand disease (VWD) is often caused by genetic defects in the vonWillebrand factor (VWF) gene and is divided into three major subtypes: type 3 (VWD3) is characterized by total absenceofVWF, type2 (VWD2)by functionaldisturbance of VWF, and type 1 (VWD1) by low plasma concentration of functionally normal VWF.1 Diagnosis of VWD is challenging due to theheterogeneity of the disease and can...

Reduced von Willebrand factor survival in type Vicenza von Willebrand disease.

Type Vicenza variant of von Willebrand disease (VWD) is characterized by a low plasma von Willebrand factor (VWF) level and supranormal VWF multimers. Two candidate mutations, G2470A and G3864A at exons 17 and 27, respectively, of the VWF gene were recently reported to be present in this disorder. Four additional families, originating from northeast Italy, with both mutations of type Vicenza VW...

Von Willebrand Factor and Von Willebrand Disease in Pregnancy – a Manageable Challenge

Repeated vaginal bleeding is a common complaint in outpatient obstetrical practice. Traditionally, it is treated with progesterone, without making an accurate etiological diagnosis. Hemorrhage during labor, delivery or postpartum period are considered obstetrical emergencies. Von Willebrand disease is one of the frequent causes for hereditary bleeding disorders; the diagnosis during pregnancy c...

von Willebrand factor binding to heparin in various types of von Willebrand disease.

INTRODUCTION The purpose was to study von Willebrand factor (vWF) binding to heparin in different types of von Willebrand disease (vWD). MATERIALS AND METHODS Plasma samples from 92 patients were representative of most vWD subtypes as they included 13 type 1, ten type 2N, 27 type 2A, 23 type 2B, and 19 type 2M patients. We selected assay conditions suitable for the screening of plasma vWF con...